Albumin is provided of many biological functions not related to its colloid-osmotic properties.
These non-oncotic functions are strictly related to the peculiar structure of the albumin molecule.
This module builds on The Albumin Molecule – Structures and Functions. It provides a deeper dive into the non-oncotic properties of albumin.
Key Takeaways
Albumin is provided of many biological functions not related to its colloid-osmotic properties.
These non-oncotic functions are strictly related to the peculiar structure of the albumin molecule.
The free Cysteine-34 residue accounts for about 80% of plasma thiol pool with reducing activity.
The N-terminal and the multimetal binding sites participate in counteracting the production of free radicals and reactive oxygen species.
Clinical and experimental evidence indicate that non-oncotic properties mediate part of the beneficial effects of albumin in patients with decompensated cirrhosis.
Based on all previous considerations, albumin is not only a plasma-expander, but it can be considered a drug for these patients.
